Date of Award

1961

Embargo Period

8-1-2024

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College

College of Graduate Studies

First Advisor

Eugene F. Woods

Second Advisor

James Richardson

Third Advisor

Richard H. Gadsden

Fourth Advisor

William M. McCord

Fifth Advisor

Thomas D. Darby

Sixth Advisor

R. P. Walton

Abstract

Reflex autonomic changes occurring with the use of cardiovascular drugs may, as a side effect, increase cardiac work and oxygen demand. Improvement of coronary flow and/or a decrease in myocardial work load without increasing oxygen utilization are the desired effects of drugs used in the treatment of coronary insufficiency. The improvement of cardiac function is the purpose of drugs used in the treatment of heart failure. In either case the therapeutic effect may be accomplished through a direct myocardial effect and/or a decrease in cardiac pressure work load through extracardiac action. Through animal experimentation and patient correlation of the many parameters involved, a better understanding of the cardiodynamic effect of these drugs may be determined. This in turn may lead to drug therapy which is more apt to alleviate symptoms than those now used for specific treatment. The following studies will be included: 1) cardiovascular changes occurring during the administration of several drugs used in the treatment of cardiovascular disease will be evaluated. 2) correction of cardiovascular depression accompanying both metabolic and respiratory acidosis will be attempted with the use of several buffers and their relative efficiency determined.

Rights

All rights reserved. Copyright is held by the author.

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