Date of Award
1971
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Biochemistry
College
College of Graduate Studies
First Advisor
John W. Zemp
Abstract
C5713L/6J mice were injected with D-amphetamine sulfate for the last six days of gestation. Their offspring were compared with those of saline-injected and untreated controls. Although the amphetamine-treated mothers gained less weight than controls during treatment and three days post partum, this did not affect litter size or body or brain weight of the offspring at birth. Injections of either drug or saline altered the rate of weight gain for the first month. The offspring of the amphetamine-treated mothers had lower levels of brain norepinephrine on the day of birth and higher levels of norepinephrine and dopamine than either control group on day 30. Their open field activity was higher than either control group on day 22, but jiggle platform activity was lower than saline controls at all times studied. The catecholamine levels of saline -injected controls were higher than those of untreated controls at days 21 and 30.
Recommended Citation
Blackwell, Ann, "The Effects of Prenatal Amphetamine Administration on Activity and the Levels of Brain Catecholamines in Young Mice" (1971). MUSC Theses and Dissertations. 122.
https://medica-musc.researchcommons.org/theses/122
Rights
All rights reserved. Copyright is held by the author.