Date of Award

1990

Embargo Period

8-1-2024

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Pharmaceutical Sciences

College

College of Graduate Studies

First Advisor

Paul J. Niebergall

Second Advisor

Gilbert Schmidt

Third Advisor

James E. Wynn

Fourth Advisor

J. Walter Sowell

Abstract

Oxygen sensitive drugs in aqueous solutions are very susceptible to oxidative degradation. Antioxidants are frequently used to protect these drugs from oxidation. A 2-level resolution VI factorial was used to evaluate a glucose oxidase-catalase-glucose system and compare it to commonly used aqueous antioxidants. The drug models used to test the effectiveness of the enzyme system were ascorbic acid, morphine sulfate, and isoproterenol hydrochloride. The glucose oxidase system successfully protected the isoproterenol hydrochloride and was significantly better than the other systems tested. The glucose oxidase system was just as effective as the other antioxidants in protecting morphine sulfate. None of the systems tested were deemed satisfactory for ascorbic acid.

Rights

All rights reserved. Copyright is held by the author.

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