Date of Award

2012

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College

College of Health Professions

First Advisor

Kit N. Simpson

Second Advisor

Andrew M. Atz

Third Advisor

Scott M. Bradley

Fourth Advisor

Charles Ellis, Jr.

Fifth Advisor

John S. Ikonomidis

Abstract

Complex congenital heart disease is a common birth defect requiring surgery soon after birth. Surgery can use a complete interruption of cerebral blood flow (DHCA) or it can be performed using regional low flow perfusion (RLFP). Either approach places the neonate at risk for oxygen deprivation resulting in neurodevelopmental impairment and Attention Deficit/Hyperactivity Disorder (ADHD). RLFP has been widely adopted but its effect on ADHD has not been elucidated. We extracted surgical records data and surveyed parents of 5-16 year old children who had neonatal surgery using DHCA or RLFP in 1995-2006 to determine the prevalence of ADHD after DHCA vs. RLFP. ADHD was negatively associated with increased RLFP time (p < .05) when controlling for DHCA time, and a primary diagnosis of interrupted aortic arch. This finding confirms that use of RLFP is associated with a reduced incidence of ADHD.

Rights

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