Date of Award
2016
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Neuroscience
College
College of Graduate Studies
First Advisor
Jens H. Jensen
Second Advisor
Leonardo Bonilha
Third Advisor
Joseph A. Helpern
Fourth Advisor
Mark A. Eckert
Fifth Advisor
Maria V. Spampinato
Abstract
Diffusion MRI (dMRI) is a powerful, non-invasive tool for probing the structural organization of the human brain. Quantitative dMRI analyses provide unique capabilities for the characterization of tissue microstructure as well as imaging contrast that is not available to other modalities. White matter tractography relies on dMRI and is currently the only non-invasive technique for mapping structural connections in the human brain. In this chapter, we will describe diffusional kurtosis imaging, an effective and versatile dMRI technique, and discuss a clinical problem in temporal lobe epilepsy (TLE) which is insurmountable with current diagnostic approaches. Subsequent chapters will further develop the capabilities of DKI and demonstrate how it may be particularly well suited to overcome current barriers to care in the clinical management of TLE.
Recommended Citation
Glenn, G. Russell, "Development of Advanced, Clinically Feasible Neuroimaging Methodology with Diffusional Kurtosis Imaging" (2016). MUSC Theses and Dissertations. 397.
https://medica-musc.researchcommons.org/theses/397
Rights
All rights reserved. Copyright is held by the author.