Date of Award
1959
Document Type
Thesis
Degree Name
Master of Science (MS)
College
College of Graduate Studies
First Advisor
Thomas D. Darby
Second Advisor
Eugene F. Woods
Third Advisor
T. B. Calhoun
Fourth Advisor
William M. McCord
Abstract
It is well known that when the body is subjected to various stress conditions there is almost always a reflex release of certain neurohumoral substances in an attempt to compensate for these abnormal conditions. Acid-base changes, for example, are some of the most frequent occurring under these conditions. As mentioned throughout this thesis there is a direct correlation between acidosis end extreme hypotension or shock. The objective of these experiments was to investigate and determine the influence of acidosis on the cardiovascular response to the sympatho-adrenal hormones, arterenol and epinephrine, which are released in large amounts during shock. These studies included: 1) the influence of metabolic acidosis on the responsiveness of the myocardium to epinephrine and arterenol, 2) the role of endogenous release of epinephrine and arterenol in contributing to metabolic acidosis and loss of responsiveness to these amines and 3) the production of acidosis by exogenous intravenous infusion of lactic acid, arterenol or epinephrine.
Recommended Citation
Aldinger, Earl E., "A Study of the Influence of Acid-Base Changes on Myocardial and Vasopressor Responses to Arterenol and Epinephrine" (1959). MUSC Theses and Dissertations. 21.
https://medica-musc.researchcommons.org/theses/21
Rights
All rights reserved. Copyright is held by the author.