Date of Award

1956

Embargo Period

8-1-2024

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Pharmacology

College

College of Graduate Studies

First Advisor

R. P. Walton

Second Advisor

William M. McCord

Abstract

In the past few years general hypothermia has been investigated as a means of reducing the oxygen requirements of the body sufficiently to allow exclusion of the heart from the circulation and thus permit intracardiac surgery under direct vision. There is also an important group of patients whose poor physical condition precludes radical surgery of any type. If the oxygen demands of the brain and other vital organs can be sufficiently reduced by hypothermia, it is conceivable that these patients would be able to withstand the shock of reduced circulation and even peripheral vascular embarrassment for short periods of time. Hypothermia is capable of significantly reducing metabolism and of producing a “physiologic hypotension.” As such, the use of this modality suggests itself as a potentially valuable technique in a variety of conditions.

Rights

All rights reserved. Copyright is held by the author.

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