Date of Award
1983
Embargo Period
8-1-2024
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Biometry
College
College of Graduate Studies
First Advisor
Harvey L. Bank
Second Advisor
C. M. Miller
Third Advisor
Hurshell H. Hunt
Abstract
Linear regression procedures are described which give an unbiased estimate of the percent functional viability of rat polymorphonuclear leukocytes (PMN's). These statistical techniques allow discrimination between variables which result in increased PMN survival after freezing. A review of current response surface techniques was made as they relate to optimizing the functional viability of PMN's after freezing. Experimental designs based on the steepest ascent and simplex methodologies were considered. Since the hill climbing efficiency of the steepest ascent and simplex methods are comparable, the steepest ascent procedure was selected as it is more readily adaptable to a batch mode analysis.
Recommended Citation
Buchner, Leonard Edward, "The Utilization of Response Surface Techniques in Survival Experiments" (1983). MUSC Theses and Dissertations. 180.
https://medica-musc.researchcommons.org/theses/180
Rights
All rights reserved. Copyright is held by the author.