Increased Frequency of the MZ Phenotype of Alpha-l-Protease Inhibitor in Juvenile Chronic Polyarthritis

Authors

Philippe Arnaud, Medical University of South Carolina
Robert M. Gailbraith, Medical University of South Carolina
W. Page Faulk, Medical University of South Carolina
Barbara M. Ansell

Document Type

Article

Embargo Period

12-1-1977

Publication Date

12-1-1977

Abstract

Pi phenotypes of alpha-1-protease inhibitor were determined by isoelectric focusing and print immunofixation in 96 English children suffering from juvenile chronic polyarthritis. A significantly increased frequency of the MZ phenotype (10.41%) was found in comparison with a geographically matched control population (1.6%). The results of this study suggest that the possession of a Z-deficient allele of alpha-l-protease inhibitor could be a predisposing, aggravating, or perpetuating factor in the articular damage occurring in juvenile chronic polyarthritis.

Journal

Journal of Clinical Investigation

Recommended Citation

Arnaud, Philippe; Gailbraith, Robert M.; Faulk, W. Page; and Ansell, Barbara M., "Increased Frequency of the MZ Phenotype of Alpha-l-Protease Inhibitor in Juvenile Chronic Polyarthritis" (1977). MUSC Faculty Journal Articles. 63.
https://medica-musc.researchcommons.org/facarticles/63