Application Of Digital Signal Analysis, Mass Data Acquisition and Processing Techniques, and Automated Experiment Protocols to the Study of Cardiac Cell Membrane Electrophysiology, with Mathematical Modeling
Date of Award
Doctor of Philosophy (PhD)
College of Graduate Studies
John M. Gibson
Traditional methods of collecting, analyzing and storing data from cardiac cell membrane electrophysiology experiments have become increasingly cumbersome and unwieldy as experimental protocols have become more sophisticated and complex. A global approach to collecting, analyzing, refining and storing electrophysiologic data, as well as a new approach to mathematical modeling of cell membrane single ion channel kinetics, was developed. This utilizes a comprehensive microcomputer based system of software with specialized analog and digital electronics for data acquisition, analysis and archiving. Unique discrete signal processing techniques for characterizing the electronic recording system, including specialized hardware and software adapted for minimizing distortions in biosignal recordings, are discussed in detail.
Buckles, David S., "Application Of Digital Signal Analysis, Mass Data Acquisition and Processing Techniques, and Automated Experiment Protocols to the Study of Cardiac Cell Membrane Electrophysiology, with Mathematical Modeling" (1987). MUSC Theses and Dissertations. 182.
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