Document Type
Article
Embargo Period
5-1-1988
Publication Date
5-1-1988
Abstract
The possible role of group specific component (Gc) (vitamin D-binding protein) in the clearance of cellular actin entering the circulation was examined with 125I-labeled Gc and actin injected into a rabbit model. Although filamentous F-actin is depolymerized primarily by plasma gelsolin, ≧ 90% 125I-actin injected in either monomeric G- or F-form became complexed eventually with Gc (1:1 molar ratio). Clearance of Gc complexes was much faster (> 90% within 5 h) than that of native Gc (t1/2 = 17.2 h). Nephrectomy did not significantly alter the clearance of either Gc or actin. Since Gc complexes are dramatically increased in situations of tissue necrosis such as in fulminant hepatic failure, the current results suggest a crucial role for Gc in sequestration and clearance of released cellular actin.
Journal
Journal of Clinical Investigation
Recommended Citation
Goldschmidt-Clemont, Pascal J.; Baelen, Hugo Van; Bouillon, Roger; Shook, Thomas E.; Williams, Merfyn H.; Nel, Andre E.; and Galbraith, Robert M., "Role of Group-specific Component (Vitamin D Binding Protein) in Clearance of Actin from the Circulation in the Rabbit" (1988). MUSC Faculty Journal Articles. 90.
https://medica-musc.researchcommons.org/facarticles/90