Different Neural Substrates Mediate Cocaine Seeking After Abstinence Versus Extinction Training: A Critical Role for the Dorsolateral Caudate-Putamen

Authors

Rita A. Fuchs, University of North Carolina at Chapel Hill
R. Kyle Branham, Medical University of South Carolina
Ronald E. See, Medical University of South Carolina

Document Type

Article

Embargo Period

1-1-2024

Publication Date

3-1-2006

Abstract

Cue-induced reinstatement of extinguished drug seeking is a preclinical model of relapse. However, relapse typically occurs after abstinence rather than explicit extinction training. We show that inactivation of the dorsolateral caudate–putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence. This suggests that there is limited overlap in the substrates of cocaine seeking after abstinence versus extinction, and that habit learning exerts greater control over drug seeking than regions implicated in stimulus–reward associations.

Journal

Journal of Neuroscience

DOI

doi: https://doi.org/10.1523/JNEUROSCI.5146-05.2006

Recommended Citation

Fuchs, Rita A.; Branham, R. Kyle; and See, Ronald E., "Different Neural Substrates Mediate Cocaine Seeking After Abstinence Versus Extinction Training: A Critical Role for the Dorsolateral Caudate-Putamen" (2006). MUSC Faculty Journal Articles. 140.
https://medica-musc.researchcommons.org/facarticles/140